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Weak signal detection is always an issue in most astrophysical cases (e.g. high redshift galaxies, faint lines in proto-planetary disks, to cite some).
For spectral lines, IMAGER offers the UV_DETECT command, that uses an image model as an optimal filter to enhance weak line detection. This is a generic tool, that can use an observed data cube (from a strong line, presumably) as the image model, or the result of a simulation.